Documents from the SIAIP Commissions

Issue 3 - 2024

HPV Vaccines: state of the art and novel approaches

Authors

SIAIP Vaccine Committee , Giusella Maria Francesca Moscato , Elisabetta Del Duca , Mayla Sgrulletti , Alessandra Beni , Giorgio Costagliola , Maria Felicia Mastrototaro , Davide Montin , Giorgio Ottaviano , Veronica Santilli , Caterina Rizzo , Baldassarre Martire , Viviana Moschese

Key words: alphaHPV, vaccines, VLP-L1, VLP-L2
DOI: 10.53151/2531-3916/2024-532
Publication Date: 2024-10-07

Abstract

High-risk genotypes of Human Papillomavirus (HPV) are responsible for cervical cancer and have been shown to be related to the occurrence of other less frequent malignancies (vulva, penis, anus, head and neck). Although in the majority of cases the infection resolves spontaneously, some people fail to clear the virus with an increased risk of neoplastic development. In Italy, HPV vaccination is recommended and offered free of charge to girls and boys from 11 years of age. It is also recommended for immunocompromised patients, individuals with high risk sexual behavior, and women with cervical lesions. The efficacy of HPV vaccination in preventing cervical cancer, especially in uninfected women, has been widely demonstrated. Further advances in technology to improve the efficacy of existing vaccines and the development of novel vaccines are necessary to prevent HPV-associated cancers. The aim of this non-systematic review is to provide an update on the available vaccines and future perspectives for HPV vaccination

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Authors

SIAIP Vaccine Committee - SIAIP

Giusella Maria Francesca Moscato - Department of System Medicine, University of Rome Tor Vergata, Rome, Italy

Elisabetta Del Duca - Pediatric Immunopathology and Allergology Unit, Policlinico Tor Vergata, University of Tor Vergata, Rome, Italy

Mayla Sgrulletti - Pediatric Immunopathology and Allergology Unit, Policlinico Tor Vergata, University of Tor Vergata, Rome, Italy

Alessandra Beni - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

Giorgio Costagliola - Section of Pediatric Hematology and Oncology, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy

Maria Felicia Mastrototaro - UOC of Pediatrics and Neonatology, “Monsignor A.R. Dimiccoli” Hospital, Barletta, Italy

Davide Montin - Division of Pediatric Immunology and Rheumatology, Department of Public Health and Pediatrics, “Regina Margherita” Children Hospital, University of Turin, Turin, Italy

Giorgio Ottaviano - Department of Pediatrics, Fondazione IRCCS San Gerardo Dei Tintori, Monza, Italy

Veronica Santilli - Academic Department of Pediatrics (DPUO), Research Unit of Clinical Immunology and Vaccinology, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy

Caterina Rizzo - Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

Baldassarre Martire - UOC of Pediatrics and Neonatology, “Monsignor A.R. Dimiccoli” Hospital, Barletta, Italy

Viviana Moschese - Pediatric Immunopathology and Allergology Unit, Policlinico Tor Vergata, University of Tor Vergata, Rome, Italy

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright

Copyright (c) 2024 Italian Journal of Pediatric Allergy and Immunology

How to Cite
Committee, S. V., Moscato, G. M. F., Del Duca, E., Sgrulletti, M., Beni, A., Costagliola, G., Mastrototaro, M. F., Montin, D., Ottaviano, G., Santilli, V., Rizzo, C., Martire, B., & Moschese, V. (2024). HPV Vaccines: state of the art and novel approaches. Italian Journal of Pediatric Allergy and Immunology, 38(3). https://doi.org/10.53151/2531-3916/2024-532
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