Plant-Based Remedies for Cough: Revisiting Traditional Approaches in the Modern Era

References

1. Pecoraro L, Peterle E, Dalla Benetta E et al. Well-Established and Traditional Use of Vegetal Extracts as an Approach to the “Deep Roots” of Cough. Children (Basel) 2024;11:584. https://doi.org/10.3390/children11050584.
2. Jerry Yu. Cough sensory mechanism -- Multiple sensor theory in airway mechanosensory units. Physiology 2023;38(S1). https://doi.org/10.1152/physiol.2023.38.S1.5730236
3. Andrani F, Aiello M, Bertorelli G, et al A. Cough, a vital reflex. mechanisms, determinants and measurements. Acta Biomed 2019;89:477-480. https://doi.org/10.23750/abm.v89i4.6182.
4. Mutolo D. Brainstem mechanisms underlying the cough reflex and its regulation. Respir Physiol Neurobiol 2017;243:60-76. https://doi.org/10.1016/j.resp.2017.05.008.
5. Abdulqawi R. Mechanistic and therapeutic evaluations of chronic cough. 1 Aug 2014.
6. Woodcock A, Young EC, Smith JA. New insights in cough. Br Med Bull 2010;96:61-73. https://doi.org/10.1093/bmb/ldq034.
7. Keller JA, McGovern AE, Mazzone SB. Translating Cough Mechanisms Into Better Cough Suppressants. Chest 2017;152:833-841. https://doi.org/10.1016/j.chest.2017.05.016.
8. Malanicheva TG, Ziatdinova NV, Kuznetsova OY, et al Cough in children: features of diagnosis and choice of therapy. Med Counc 2024:40-45. https://doi.org/10.21518/ms2023-483.
9. Schmidt M, Thomsen M, Schmidt U. Suitability of ivy extract for the treatment of paediatric cough. Phytother Res 2012;26:1942-1947. https://doi.org/10.1002/ptr.4671.
10. Shokry AA, El-Shiekh RA, Kamel G, et al. Bioactive phenolics fraction of Hedera helix L. (Common Ivy Leaf) standardized extract ameliorates LPS-induced acute lung injury in the mouse model through the inhibition of proinflammatory cytokines and oxidative stress. Heliyon 2022;8:e09477. https://doi.org/10.1016/j.heliyon.2022.e09477.
11. Vakhitov KM, Pikuza OI, Karpova OA, et al. Natural cough remedies: options for a rational choice. Meditsinskiy Sovet 2022;(19):36-41. https://doi.org/10.21518/2079-701X-2022-16-19-36-41.
12. Kolosova NG, Denisova VD, Denisova AR, et al. The role of herbal medicines in treating cough in children. Meditsinskiy sovet = Medical Council 2022;(1):58-63. https://doi.org/10.21518/2079-701x-2022-16-1-58-63.
13. Lazareva NB, Karnoukh KI. Herbal medicines: current use in the treatment of respiratory infections. Meditsinskiy sovet = Medical Council 2020;(17):114-122. https://doi.org/10.21518/2079-701X-2020-17-114-122.
14. Toma L, Raileanu M, Deleanu M, et al. Novel molecular mechanisms by which ginger extract reduces the inflammatory stress in TNFα – activated human endothelial cells; decrease of Ninjurin-1, TNFR1 and NADPH oxidase subunits expression. J Funct Foods 2018;48:654-664. https://doi.org/10.1016/j.jff.2018.08.011
15. Kulkarni RA, Deshpande AR. Anti-inflammatory and antioxidant effect of ginger in tuberculosis. J Complement Integr Med 2016;13:201-206. https://doi.org/10.1515/jcim-2015-0032.
16. Khan MF, Akram M, Akhter N, et al. The evaluation ofefficacy and safety of Cough (EMA) granules used for upper respiratory disorders. Pak J Pharm Sci 2018;31(6 (Suppl):2617-2622.
17. Zannini M, Cattivelli A, Nissen L, et al. Identification, Bioaccessibility, and Antioxidant Properties of Phenolic Compounds in Carob Syrup. Foods 2024;13:2196. https://doi.org/10.3390/foods13142196.
18. EMA Committee on Herbal Medicinal Products (HMPC)EMA. European Union Herbal Monographs: Overview of Recommendations for the Uses of Herbal Medicinal Products in the Paediatric Population - 2023. https://www.ema.europa.eu/en/documents/other/european-union-herbal-monographs-overview-recommendations-uses-herbal-medicinal-products-paediatric-population_en.pdf.
19. Kantar, A. Update on Pediatric Cough. Lung 2016;194:9-14. https://doi.org/10.1007/s00408-015-9815-6